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Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase1 and cyclin-dependent kinase 5 expression in ovarian cancer

Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer
Posted by Karen

Dopamine and cyclic-AMP activated Mr32kDa phosphoprotein (DARPP-32) is a central signaling proteins in neurotransmission. Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). Increasing evidence suggests a role for DARPP-32 and signal pathways related to cancer;

However, its role in ovarian cancer remains unclear. Using immunohistochemistry, expression of DARPP-32, PP1 and Cdk5 is determined in a large cohort of primary tumors from ovarian cancer patients (n = 428, 445 and 434 respectively) to evaluate the relationship between clinical outcome and clinicopathological criteria.

Low cytoplasmic and nuclear DARPP-32 expression was associated with a shorter overall patient survival and progression-free survival (P = 0.001, 0.001, 0.004 and 0.037 respectively). Low nuclear and cytoplasmic DARPP-32 expression remained significantly associated with overall survival in multivariate Cox regression (P = 0.045, hazard ratio (HR) = 0.734, 95% confidence interval (CI) = 0.542 to 0.993 and P = 0.001, HR = 0.494, 95% CI = 0.325 to 0.749, respectively).

cytoplasmic and nuclear high PP1 expression was associated with a shorter overall patient survival and expression of cytoplasmic PP1 high with progression-free survival shorter (P = 0.005, 0.033, and 0.037, respectively). Cdk5 high expression was associated with progression-free survival shorter (P = 0.006). These data demonstrate the role of DARPP-32 and related kinase signaling as a prognostic marker in ovarian cancer clinical utility.

Dopamine and cAMP-regulated phospho<em>protein</em> 32kDa (DARPP-32), <em>protein</em> <em>phosphatase</em>-<em>1</em> and cyclin-dependent kinase 5 expression in ovarian cancer
Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase1 and cyclin-dependent kinase 5 expression in ovarian cancer

Protein phosphatase one alpha Increase glucocorticoid receptor activity by a mechanism that involves phosphorylation of serine-2 one one < / em>

By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. A disturbed regulation of glucocorticoid action has been associated with various disorders. Thus, an explanation of the underlying signaling pathway is important for understanding the mechanisms of glucocorticoid impaired function and contribute to disease.

This study found an increase in excess GR transcriptional activity of protein phosphatase 1 alpha (PP1α) in HEK-293 cells and a decrease in the expression levels of GR-responsive gene knockdown following PP1α model A549 cells endogenously. Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3).

Thus, this study identified PP1α as a novel post-translational activator of GR signaling, indicating that PP1α function disorders can lead to disorders glucocorticoid action and thereby contribute to diseases.Ewing sarcoma (ES) is a pediatric malignant bone and soft tissue tumors. Patients with metastatic ES have dismal outcomes were not improved in decades. The major challenge in the treatment of metastatic ES is the lack of specific targets and rational combination therapy.

PPP1CA

MBS8565100-01mL 0.1mL
EUR 345

PPP1CA

MBS8565100-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA

MBS8565100-01mLAF405S 0.1mL(AF405S)
EUR 565

PPP1CA

MBS8565100-01mLAF610 0.1mL(AF610)
EUR 565

PPP1CA

MBS8565100-01mLAF635 0.1mL(AF635)
EUR 565

PPP1CA siRNA

20-abx904171
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  • 15 nmol
  • 30 nmol

PPP1CA siRNA

20-abx929453
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  • 15 nmol
  • 30 nmol

PPP1CA siRNA

20-abx929454
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  • 15 nmol
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PPP1CA antibody

10R-1069 100 ul
EUR 320
Description: Mouse monoclonal PPP1CA antibody

PPP1CA Antibody

32649-100ul 100ul
EUR 302.4

PPP1CA Antibody

E19-6907 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

E230001-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PPP1CA Antibody

E230001-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

CSB-PA018503KA01HU- each
EUR 402
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PPP1CA Antibody

CSB-PA018503KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PPP1CA Antibody

1-CSB-PA018503LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

PPP1CA Antibody

DF6907 200ul
EUR 420

PPP1CA Antibody

DF6907-100ul 100ul
EUR 280

PPP1CA Antibody

DF6907-200ul 200ul
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PPP1CA Antibody

DF2991 200ul
EUR 420

PPP1CA Antibody

DF2991-100ul 100ul
EUR 280

PPP1CA Antibody

DF2991-200ul 200ul
EUR 350

PPP1CA Antibody

E220015-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PPP1CA Antibody

E220015-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

E92184 100ul
EUR 255
Description: Available in various conjugation types.

PPP1CA Antibody

E220159-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PPP1CA Antibody

E220159-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

BF0683-100ul 100ul
EUR 350

PPP1CA Antibody

BF0683-200ul 200ul
EUR 450

PPP1CA Antibody

BF0683-50ul 50ul
EUR 250

PPP1CA antibody

70R-2013 50 ug
EUR 467
Description: Rabbit polyclonal PPP1CA antibody raised against the N terminal of PPP1CA

PPP1CA Antibody

AF6638 100ul
EUR 420

PPP1CA Antibody

AF6638-100ul 100ul
EUR 280

PPP1CA Antibody

AF6638-200ul 200ul
EUR 350

PPP1CA Antibody

1-CSB-PA030161
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

PPP1CA Antibody

ABD6907 100ug
EUR 325

PPP1CA Antibody

GWB-MV344B 50ug Ask for price

PPP1CA antibody

BF0683 100ug
EUR 355

PPP1CA Antibody

MBS7052277-005mg 0.05mg
EUR 190

PPP1CA Antibody

MBS7052277-01mg 0.1mg
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PPP1CA Antibody

MBS7052277-5x01mg 5x0.1mg
EUR 1205

PPP1CA Antibody

MBS7120200-005mg 0.05mg
EUR 150

PPP1CA Antibody

MBS7120200-01mg 0.1mg
EUR 190

PPP1CA Antibody

MBS7120200-5x01mg 5x0.1mg
EUR 845

PPP1CA Antibody

MBS850023-005mg 0.05mg
EUR 235

PPP1CA Antibody

MBS850023-01mg 0.1mg
EUR 305

PPP1CA Antibody

MBS850023-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA Antibody

MBS850023-01mLAF405S 0.1mL(AF405S)
EUR 565

PPP1CA Antibody

MBS850023-01mLAF610 0.1mL(AF610)
EUR 565

PPP1CA Antibody

MBS8504967-01mL 0.1mL
EUR 325

PPP1CA Antibody

MBS8504967-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA Antibody

MBS8504967-01mLAF405S 0.1mL(AF405S)
EUR 565

PPP1CA Antibody

MBS8504967-01mLAF610 0.1mL(AF610)
EUR 565

PPP1CA Antibody

MBS8504967-01mLAF635 0.1mL(AF635)
EUR 565

PPP1CA Antibody

MBS8516377-01mg 0.1mg
EUR 305

PPP1CA Antibody

MBS8516377-01mLAF405L 0.1mL(AF405L)
EUR 465

PPP1CA Antibody

MBS8516377-01mLAF405S 0.1mL(AF405S)
EUR 465

PPP1CA Antibody

MBS8516377-01mLAF610 0.1mL(AF610)
EUR 465

PPP1CA Antibody

MBS8516377-01mLAF635 0.1mL(AF635)
EUR 465

PPP1CA Antibody

MBS8502669-005mg 0.05mg
EUR 235

PPP1CA Antibody

MBS8502669-01mg 0.1mg
EUR 305

PPP1CA Antibody

MBS8502669-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA Antibody

MBS8502669-01mLAF405S 0.1mL(AF405S)
EUR 565

PPP1CA Antibody

MBS8502669-01mLAF610 0.1mL(AF610)
EUR 565

PPP1CA Antibody

MBS8526887-005mg 0.05mg
EUR 235

PPP1CA Antibody

MBS8526887-01mg 0.1mg
EUR 305

PPP1CA Antibody

MBS8526887-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA Antibody

MBS8526887-01mLAF405S 0.1mL(AF405S)
EUR 565

PPP1CA Antibody

MBS8526887-01mLAF610 0.1mL(AF610)
EUR 565

PPP1CA antibody

MBS200069-005mL 0.05mL
EUR 260

PPP1CA antibody

MBS200069-01mL 0.1mL
EUR 345

PPP1CA antibody

MBS200069-5x01mL 5x0.1mL
EUR 1300

PPP1CA Antibody

MBS9613659-01mL 0.1mL
EUR 260

PPP1CA Antibody

MBS9613659-02mL 0.2mL
EUR 305

PPP1CA Antibody

MBS9613659-5x02mL 5x0.2mL
EUR 1220

PPP1CA Antibody

MBS9607560-01mL 0.1mL
EUR 260

PPP1CA Antibody

MBS9607560-02mL 0.2mL
EUR 305

PPP1CA Antibody

MBS9607560-5x02mL 5x0.2mL
EUR 1220

PPP1CA/PPP1CB Antibody

DF2954 200ul
EUR 420

PPP1CA/PPP1CB Antibody

DF2954-100ul 100ul
EUR 280

PPP1CA/PPP1CB Antibody

DF2954-200ul 200ul
EUR 350

PPP1CA Mouse mAb

E2220649 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA siRNA (Rat)

MBS8229787-15nmol 15nmol
EUR 405

PPP1CA siRNA (Rat)

MBS8229787-30nmol 30nmol
EUR 565

PPP1CA siRNA (Rat)

MBS8229787-5x30nmol 5x30nmol
EUR 2450

PPP1CA Mouse mAb

MBS8538856-01mL 0.1mL
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PPP1CA Mouse mAb

MBS8538856-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA Mouse mAb

MBS8538856-01mLAF405S 0.1mL(AF405S)
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PPP1CA Mouse mAb

MBS8538856-01mLAF610 0.1mL(AF610)
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PPP1CA Mouse mAb

MBS8538856-01mLAF635 0.1mL(AF635)
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PPP1CA Rabbit pAb

A12468-100ul 100 ul
EUR 369.6

PPP1CA Rabbit pAb

A12468-200ul 200 ul
EUR 550.8

PPP1CA Rabbit pAb

A12468-20ul 20 ul
EUR 219.6

PPP1CA Rabbit pAb

A12468-50ul 50 ul
EUR 267.6

PPP1CA Rabbit pAb

E2511111 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA cDNA Clone

MBS1267013-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 200

PPP1CA cDNA Clone

MBS1267013-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 855

PPP1CA Rabbit pAb

MBS8548362-01mL 0.1mL
EUR 305

PPP1CA Rabbit pAb

MBS8548362-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA Rabbit pAb

MBS8548362-01mLAF405S 0.1mL(AF405S)
EUR 565

PPP1CA Rabbit pAb

MBS8548362-01mLAF610 0.1mL(AF610)
EUR 565

PPP1CA Rabbit pAb

MBS8548362-01mLAF635 0.1mL(AF635)
EUR 565

PPP1CA Rabbit pAb

A12468 20μL
EUR 623.48

PPP1CA Rabbit pAb

A2184 200μL
EUR 623.48

PPP1CA Rabbit mAb

A24288 50μL
EUR 226.72

PPP1CA siRNA (Human)

MBS8217346-15nmol 15nmol
EUR 405

PPP1CA siRNA (Human)

MBS8217346-30nmol 30nmol
EUR 565

PPP1CA siRNA (Human)

MBS8217346-5x30nmol 5x30nmol
EUR 2450

PPP1CA siRNA (Mouse)

MBS8227969-15nmol 15nmol
EUR 405

PPP1CA siRNA (Mouse)

MBS8227969-30nmol 30nmol
EUR 565

PPP1CA siRNA (Mouse)

MBS8227969-5x30nmol 5x30nmol
EUR 2450

PPP1CA + 1CB Antibody

45032-100ul 100ul
EUR 302.4

PPP1CA + 1CB Antibody

45032-50ul 50ul
EUR 224.4

PPP1CA + 1CB Antibody

20-abx217900
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  • 100 ug
  • 50 ug

PPP1CA + 1CB Antibody

E19-2954-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

PPP1CA + 1CB Antibody

E19-2954-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA + 1CB Antibody

ABD2954 100ug
EUR 325

PPP1CA + 1CB Antibody

MBS8513637-005mg 0.05mg
EUR 235

PPP1CA + 1CB Antibody

MBS8513637-01mg 0.1mg
EUR 305

PPP1CA + 1CB Antibody

MBS8513637-01mLAF405M 0.1mL(AF405M)
EUR 465

PPP1CA + 1CB Antibody

MBS8513637-01mLAF546 0.1mL(AF546)
EUR 465

PPP1CA + 1CB Antibody

MBS8513637-01mLAF750 0.1mL(AF750)
EUR 465

PPP1CA + 1CB Antibody

MBS9604423-01mL 0.1mL
EUR 260

PPP1CA + 1CB Antibody

MBS9604423-02mL 0.2mL
EUR 305

PPP1CA + 1CB Antibody

MBS9604423-5x02mL 5x0.2mL
EUR 1220

PPP1CA cloning plasmid

CSB-CL018503HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the PPP1CA gene.

PPP1CA Blocking Peptide

33R-6411 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PPP1CA antibody, catalog no. 70R-2013

PPP1CA Blocking Peptide

DF6907-BP 1mg
EUR 234

PPP1CA Blocking Peptide

BF0683-BP 1mg
EUR 234

PPP1CA Blocking Peptide

MBS9620267-1mg 1mg
EUR 380

PPP1CA Blocking Peptide

MBS9620267-5x1mg 5x1mg
EUR 1650

PPP1CA Blocking Peptide

MBS9617740-1mg 1mg
EUR 380

PPP1CA Blocking Peptide

MBS9617740-5x1mg 5x1mg
EUR 1650

PPP1CA Blocking Peptide

MBS9623172-1mg 1mg
EUR 380

PPP1CA Blocking Peptide

MBS9623172-5x1mg 5x1mg
EUR 1650

PPP1CA Blocking Peptide

MBS9626276-1mg 1mg
EUR 380

PPP1CA Blocking Peptide

MBS9626276-5x1mg 5x1mg
EUR 1650

Human Recombinant PPP1CA

6370-10 each
EUR 483.6

PPP1CA+PPP1CB Rabbit pAb

E2380759 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA+PPP1CB Rabbit pAb

MBS8542224-01mL 0.1mL
EUR 305

PPP1CA+PPP1CB Rabbit pAb

MBS8542224-01mLAF405L 0.1mL(AF405L)
EUR 565

PPP1CA+PPP1CB Rabbit pAb

MBS8542224-01mLAF405S 0.1mL(AF405S)
EUR 565

PPP1CA+PPP1CB Rabbit pAb

MBS8542224-01mLAF610 0.1mL(AF610)
EUR 565

PPP1CA+PPP1CB Rabbit pAb

MBS8542224-01mLAF635 0.1mL(AF635)
EUR 565

PPP1CA Protein (Recombinant)

20-abx073956
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  • 1 µg
  • 50 ug
  • 5 ug

PPP1CA Monoclonal Antibody

27087-100ul 100ul
EUR 302.4

PPP1CA Monoclonal Antibody

27087-50ul 50ul
EUR 224.4

PPP1CA Polyclonal Antibody

E912468 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA Conjugated Antibody

C32649 100ul
EUR 476.4

PPP1CA Polyclonal Antibody

E-AB-92438-120uL 120uL
EUR 320
Description: Unconjugated

PPP1CA Polyclonal Antibody

E-AB-92438-200uL 200uL
EUR 530
Description: Unconjugated

PPP1CA Polyclonal Antibody

E-AB-92438-60uL 60uL
EUR 200
Description: Unconjugated

We recently discovered a protein phosphatase 1 regulatory subunit 1A (PPP1R1A) specifically highly expressed in ES and promote tumor growth and metastasis in ES. In the current investigation, we showed that PPP1R1A regulate ES cell growth cycle at the G1 / S phase to down-regulate the cell cycle inhibitor p21Cip1 and p27KIP1, which leads to retinoblastoma (Rb) protein hyperphosphorylation. In addition, we show that the normal transcription PPP1R1A promotes histone genes during cell cycle progression.

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