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Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase1 and cyclin-dependent kinase 5 expression in ovarian cancer

Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer
Posted by Karen

Dopamine and cyclic-AMP activated Mr32kDa phosphoprotein (DARPP-32) is a central signaling proteins in neurotransmission. Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). Increasing evidence suggests a role for DARPP-32 and signal pathways related to cancer;

However, its role in ovarian cancer remains unclear. Using immunohistochemistry, expression of DARPP-32, PP1 and Cdk5 is determined in a large cohort of primary tumors from ovarian cancer patients (n = 428, 445 and 434 respectively) to evaluate the relationship between clinical outcome and clinicopathological criteria.

Low cytoplasmic and nuclear DARPP-32 expression was associated with a shorter overall patient survival and progression-free survival (P = 0.001, 0.001, 0.004 and 0.037 respectively). Low nuclear and cytoplasmic DARPP-32 expression remained significantly associated with overall survival in multivariate Cox regression (P = 0.045, hazard ratio (HR) = 0.734, 95% confidence interval (CI) = 0.542 to 0.993 and P = 0.001, HR = 0.494, 95% CI = 0.325 to 0.749, respectively).

cytoplasmic and nuclear high PP1 expression was associated with a shorter overall patient survival and expression of cytoplasmic PP1 high with progression-free survival shorter (P = 0.005, 0.033, and 0.037, respectively). Cdk5 high expression was associated with progression-free survival shorter (P = 0.006). These data demonstrate the role of DARPP-32 and related kinase signaling as a prognostic marker in ovarian cancer clinical utility.

Dopamine and cAMP-regulated phospho<em>protein</em> 32kDa (DARPP-32), <em>protein</em> <em>phosphatase</em>-<em>1</em> and cyclin-dependent kinase 5 expression in ovarian cancer
Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase1 and cyclin-dependent kinase 5 expression in ovarian cancer

Protein phosphatase one alpha Increase glucocorticoid receptor activity by a mechanism that involves phosphorylation of serine-2 one one < / em>

By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. A disturbed regulation of glucocorticoid action has been associated with various disorders. Thus, an explanation of the underlying signaling pathway is important for understanding the mechanisms of glucocorticoid impaired function and contribute to disease.

This study found an increase in excess GR transcriptional activity of protein phosphatase 1 alpha (PP1α) in HEK-293 cells and a decrease in the expression levels of GR-responsive gene knockdown following PP1α model A549 cells endogenously. Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3).

Thus, this study identified PP1α as a novel post-translational activator of GR signaling, indicating that PP1α function disorders can lead to disorders glucocorticoid action and thereby contribute to diseases.Ewing sarcoma (ES) is a pediatric malignant bone and soft tissue tumors. Patients with metastatic ES have dismal outcomes were not improved in decades. The major challenge in the treatment of metastatic ES is the lack of specific targets and rational combination therapy.

PPP1CA

enz-165 1µg
EUR 60
Description: Recombinant Human Protein Phosphatase 1, Catalytic Subunit Alpha

PPP1CA siRNA

20-abx904171
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  • 15 nmol
  • 30 nmol

PPP1CA siRNA

20-abx929453
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  • 15 nmol
  • 30 nmol

PPP1CA siRNA

20-abx929454
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  • Ask for price
  • 15 nmol
  • 30 nmol

PPP1CA Antibody

ABD6907 100 ug
EUR 525.6

PPP1CA antibody

10R-1069 100 ul
EUR 320
Description: Mouse monoclonal PPP1CA antibody

PPP1CA Antibody

32649-100ul 100ul
EUR 302.4

PPP1CA Antibody

E19-6907 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

E230001-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PPP1CA Antibody

E230001-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

CSB-PA018503KA01HU- each
EUR 402
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PPP1CA Antibody

CSB-PA018503KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PPP1CA Antibody

1-CSB-PA018503LA01HU
  • Ask for price
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

PPP1CA Antibody

DF6907 200ul
EUR 420

PPP1CA Antibody

DF6907-100ul 100ul
EUR 280

PPP1CA Antibody

DF6907-200ul 200ul
EUR 350

PPP1CA Antibody

DF2991 200ul
EUR 420

PPP1CA Antibody

DF2991-100ul 100ul
EUR 280

PPP1CA Antibody

DF2991-200ul 200ul
EUR 350

PPP1CA Antibody

E220015-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PPP1CA Antibody

E220015-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

E92184 100ul
EUR 255
Description: Available in various conjugation types.

PPP1CA Antibody

E220159-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PPP1CA Antibody

E220159-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1CA Antibody

BF0683 200ul
EUR 540

PPP1CA Antibody

BF0683-100ul 100ul
EUR 350

PPP1CA Antibody

BF0683-200ul 200ul
EUR 450

PPP1CA Antibody

BF0683-50ul 50ul
EUR 250

PPP1CA antibody

70R-2013 50 ug
EUR 467
Description: Rabbit polyclonal PPP1CA antibody raised against the N terminal of PPP1CA

PPP1CA Antibody

AF6638 100ul
EUR 420

PPP1CA Antibody

AF6638-100ul 100ul
EUR 280

PPP1CA Antibody

AF6638-200ul 200ul
EUR 350

PPP1CA Antibody

1-CSB-PA030161
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

PPP1CA Antibody

GWB-MV344B 50ug Ask for price

PPP1CA/PPP1CB Antibody

DF2954 200ul
EUR 420

PPP1CA/PPP1CB Antibody

DF2954-100ul 100ul
EUR 280

PPP1CA/PPP1CB Antibody

DF2954-200ul 200ul
EUR 350

PPP1CA Mouse mAb

E2220649 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA Rabbit pAb

A12468-100ul 100 ul
EUR 369.6

PPP1CA Rabbit pAb

A12468-200ul 200 ul
EUR 550.8

PPP1CA Rabbit pAb

A12468-20ul 20 ul
EUR 219.6

PPP1CA Rabbit pAb

A12468-50ul 50 ul
EUR 267.6

PPP1CA Rabbit pAb

E2511111 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA + 1CB Antibody

45032-100ul 100ul
EUR 302.4

PPP1CA + 1CB Antibody

45032-50ul 50ul
EUR 224.4

PPP1CA + 1CB Antibody

20-abx217900
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  • 100 ug
  • 50 ug

PPP1CA + 1CB Antibody

E19-2954-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

PPP1CA + 1CB Antibody

E19-2954-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA + 1CB Antibody

ABD2954 100 ug
EUR 525.6

PPP1CA cloning plasmid

CSB-CL018503HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the PPP1CA gene.

PPP1CA Blocking Peptide

33R-6411 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PPP1CA antibody, catalog no. 70R-2013

PPP1CA Blocking Peptide

DF6907-BP 1mg
EUR 234

PPP1CA Blocking Peptide

BF0683-BP 1mg
EUR 234

Human Recombinant PPP1CA

6370-10 each
EUR 483.6

PPP1CA+PPP1CB Rabbit pAb

E2380759 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA Protein (Recombinant)

20-abx073956
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  • 1 µg
  • 50 ug
  • 5 ug

PPP1CA Monoclonal Antibody

27087-100ul 100ul
EUR 302.4

PPP1CA Monoclonal Antibody

27087-50ul 50ul
EUR 224.4

PPP1CA Polyclonal Antibody

E912468 100ul
EUR 225
Description: Available in various conjugation types.

PPP1CA Conjugated Antibody

C32649 100ul
EUR 476.4

PPP1CA Polyclonal Antibody

E-AB-92438-120uL 120uL
EUR 320
Description: Unconjugated

PPP1CA Polyclonal Antibody

E-AB-92438-200uL 200uL
EUR 530
Description: Unconjugated

PPP1CA Polyclonal Antibody

E-AB-92438-60uL 60uL
EUR 200
Description: Unconjugated

PPP1CA Polyclonal Antibody

E-AB-92438-each each Ask for price
Description: Unconjugated

PPP1CA ELISA KIT|Human

EF006522 96 Tests
EUR 826.8

Mouse Ppp1ca ELISA KIT

ELI-36183m 96 Tests
EUR 1038

Human PPP1CA ELISA KIT

ELI-16516h 96 Tests
EUR 988.8

Human PPP1CA ELISA Kit

ELA-E9568h 96 Tests
EUR 988.8

PPP1CA protein (His tag)

80R-1935 10 ug
EUR 329
Description: Recombinant human PPP1CA protein

Bovine PPP1CA ELISA KIT

ELI-45373b 96 Tests
EUR 1113.6

Canine PPP1CA ELISA KIT

ELI-21782d 96 Tests
EUR 1113.6

Rat PPP1CA shRNA Plasmid

20-abx984590
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  • 150 µg
  • 300 µg

Mouse PPP1CA shRNA Plasmid

20-abx972168
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  • 150 µg
  • 300 µg

Human PPP1CA shRNA Plasmid

20-abx953684
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  • 150 µg
  • 300 µg

PPP1CA + 1CB Blocking Peptide

DF2954-BP 1mg
EUR 234

PPP1CA Antibody, HRP conjugated

1-CSB-PA018503LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PPP1CA + 1CB Conjugated Antibody

C45032 100ul
EUR 476.4

PPP1CA Recombinant Protein (Rat)

RP221681 100 ug Ask for price

PPP1CA Antibody, FITC conjugated

1-CSB-PA018503LC01HU
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  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD00844-1ML - PPP1CA Antibody

OACD00844-1ML 1ml
EUR 669

OAPA00300-5UG - PPP1CA Antibody

OAPA00300-5UG 5ug
EUR 69

OAAN00781-50UL - PPP1CA Antibody

OAAN00781-50UL 50ul
EUR 149

PPP1CA Recombinant Protein (Human)

RP024331 100 ug Ask for price

PPP1CA Recombinant Protein (Mouse)

RP163841 100 ug Ask for price

PPP1CA Antibody, Biotin conjugated

1-CSB-PA018503LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACD00844-100UL - PPP1CA Antibody

OACD00844-100UL 100ul
EUR 199

OAAN00781-100UL - PPP1CA Antibody

OAAN00781-100UL 100ul
EUR 249

OAAN00781-200UL - PPP1CA Antibody

OAAN00781-200UL 200ul
EUR 389

OAAB21632-100UL - PPP1CA Antibody

OAAB21632-100UL 100ul
EUR 409

OAAB21633-100UL - PPP1CA Antibody

OAAB21633-100UL 100ul
EUR 409

OAAD00196-100UG - PPP1CA Antibody

OAAD00196-100UG 100ug
EUR 289

OAAJ07381-100UL - PPP1CA Antibody

OAAJ07381-100UL 100uL
EUR 319

OAAF00913-100UG - PPP1CA Antibody

OAAF00913-100UG 100ug
EUR 329

OAEC04576-100UL - PPP1CA Antibody

OAEC04576-100UL 100ug/100ul
EUR 249

OAGA02505-100UL - PPP1CA Antibody

OAGA02505-100UL 100ul
EUR 369

Ppp1ca (untagged) - Mouse protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca), (10ug)

MC202914 10 µg Ask for price

Ppp1ca (GFP-tagged) - Mouse protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca)

MG204856 10 µg Ask for price

Ppp1ca ORF Vector (Rat) (pORF)

ORF073895 1.0 ug DNA
EUR 607.2

PPP1CA ORF Vector (Human) (pORF)

ORF008111 1.0 ug DNA
EUR 114

Ppp1ca ORF Vector (Mouse) (pORF)

ORF054615 1.0 ug DNA
EUR 607.2

PPP1CA Conjugated Monoclonal Antibody

C27087 100ul
EUR 476.4

PPP1CA ELISA Kit (Rat) (OKEH05943)

OKEH05943 96 Wells
EUR 872.4
Description: Description of target: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.171 ng/mL

PPP1CA ELISA Kit (Dog) (OKEH08782)

OKEH08782 96 Wells
EUR 1420.8
Description: Description of target: ;Species reactivity: Dog;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity:

Human PPP1CA knockout cell line

ABC-KH11993 1 vial Ask for price
Description: Human PPP1CA knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Ppp1ca (Myc-DDK-tagged) - Mouse protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca)

MR204856 10 µg Ask for price

Human PPP1CA knockdown cell line

ABC-KD11993 1 vial Ask for price
Description: Human PPP1CA knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human PPP1CA Protein Lysate 20ug

IHUPPP1CAPLLY20UG each
EUR 213
Description: Human PPP1CA Protein Lysate 20ug

PPP1CA ELISA Kit (Human) (OKEH01979)

OKEH01979 96 Wells
EUR 872.4
Description: Description of target: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.055 ng/mL

PPP1CA ELISA Kit (Mouse) (OKEH04977)

OKEH04977 96 Wells
EUR 872.4
Description: Description of target: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.17 ng/mL

PPP1CA ELISA Kit (Bovine) (OKEH06691)

OKEH06691 96 Wells
EUR 934.8
Description: Description of target: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy.;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Competitive ELISA;Sensitivity: 0.25 ng/mL

Ppp1ca (untagged ORF) - Rat protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca), (10 ug)

RN210965 10 µg Ask for price

Mouse Monoclonal Antibody to PPP1CA

E10-30307 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal Antibody to PPP1CA

sAP-0657 50ug
EUR 270

Monoclonal PPP1CA Antibody, Clone: 5E9

AMM02873G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PPP1CA. The antibodies are raised in Mouse and are from clone 5E9. This antibody is applicable in WB, E

OCOA16620-20UG - PPP1CA Protein Lysate

OCOA16620-20UG 20ug
EUR 169

OCOA00860-20UG - PPP1CA Protein Lysate

OCOA00860-20UG 20ug
EUR 169

PPP1CA Over-expression Lysate Product

GWB-8C47B0 0.1 mg Ask for price

PPP1CA Over-expression Lysate Product

GWB-6BC89F 0.1 mg Ask for price

PPP1CA Over-expression Lysate Product

GWB-FC027B 0.1 mg Ask for price

PPP1CA (untagged)-Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 3

SC127981 10 µg Ask for price

PPP1CA (untagged)-Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 1

SC319185 10 µg Ask for price

PPP1CA (untagged)-Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 2

SC308293 10 µg Ask for price

OKEH05943-96W - PPP1CA ELISA Kit (Rat)

OKEH05943-96W 96Wells
EUR 600

OKEH08782-96W - PPP1CA ELISA Kit (Dog)

OKEH08782-96W 96Wells
EUR 875

OPCD00532-10UG - PPP1CA Recombinant Protein

OPCD00532-10UG 10ug
EUR 129

OPCD00532-50UG - PPP1CA Recombinant Protein

OPCD00532-50UG 50ug
EUR 309

OPCD00532-200UG - PPP1CA Recombinant Protein

OPCD00532-200UG 200ug
EUR 619

OKEH01979-96W - PPP1CA ELISA Kit (Human)

OKEH01979-96W 96Wells
EUR 600

OKEH04977-96W - PPP1CA ELISA Kit (Mouse)

OKEH04977-96W 96Wells
EUR 600

Ppp1ca (Myc-DDK-tagged ORF) - Rat protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca), (10 ug)

RR210965 10 µg Ask for price

Ppp1ca sgRNA CRISPR Lentivector set (Rat)

K7563101 3 x 1.0 ug
EUR 406.8

OKEH06691-96W - PPP1CA ELISA Kit (Bovine)

OKEH06691-96W 96Wells
EUR 625

PPP1CA (GFP-tagged) - Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 3

RG212268 10 µg Ask for price

PPP1CA (GFP-tagged) - Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 1

RG203575 10 µg Ask for price

PPP1CA (GFP-tagged) - Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 2

RG216212 10 µg Ask for price

PPP1CA 3'UTR GFP Stable Cell Line

TU068618 1.0 ml
EUR 1672.8

Ppp1ca 3'UTR GFP Stable Cell Line

TU166799 1.0 ml Ask for price

Ppp1ca 3'UTR GFP Stable Cell Line

TU266644 1.0 ml Ask for price

PPP1A (PPP1CA) rabbit polyclonal antibody, Serum

AP55265SU-N 200 µl Ask for price

PPP1CA sgRNA CRISPR Lentivector set (Human)

K1701701 3 x 1.0 ug
EUR 406.8

Ppp1ca sgRNA CRISPR Lentivector set (Mouse)

K3345601 3 x 1.0 ug
EUR 406.8

Lenti ORF clone of Ppp1ca (mGFP-tagged) - Mouse protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca)

MR204856L4 10 µg Ask for price

PPP1A (PPP1CA) sheep polyclonal antibody, Purified

AP05033PU-N 100 µg Ask for price

PPP1A (PPP1CA) rabbit polyclonal antibody, Purified

AP05032PU-N 100 µg Ask for price

PPP1CA Protein Vector (Rat) (pPM-C-HA)

PV295580 500 ng
EUR 723.6

PPP1CA Protein Vector (Rat) (pPB-C-His)

PV295578 500 ng
EUR 723.6

PPP1CA Protein Vector (Rat) (pPB-N-His)

PV295579 500 ng
EUR 723.6

PPP1CA Protein Vector (Rat) (pPM-C-His)

PV295581 500 ng
EUR 723.6

Lenti ORF clone of Ppp1ca (Myc-DDK-tagged) - Mouse protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca)

MR204856L3 10 µg Ask for price

PPP1CA (Myc-DDK-tagged)-Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 1

RC203575 10 µg Ask for price

PPP1CA (Myc-DDK-tagged)-Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 2

RC216212 10 µg Ask for price

PPP1CA (Myc-DDK-tagged)-Human protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 3

RC212268 10 µg Ask for price

We recently discovered a protein phosphatase 1 regulatory subunit 1A (PPP1R1A) specifically highly expressed in ES and promote tumor growth and metastasis in ES. In the current investigation, we showed that PPP1R1A regulate ES cell growth cycle at the G1 / S phase to down-regulate the cell cycle inhibitor p21Cip1 and p27KIP1, which leads to retinoblastoma (Rb) protein hyperphosphorylation. In addition, we show that the normal transcription PPP1R1A promotes histone genes during cell cycle progression.

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Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Uncategorized, Vector & Virus, Western Blot

SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase1.

SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1.
Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Uncategorized, Vector & Virus, Western Blot

Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase1 and cyclin-dependent kinase 5 expression in ovarian cancer

Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer

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