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Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase1 and cyclin-dependent kinase 5 expression in ovarian cancer

Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer
Posted by Karen

Dopamine and cyclic-AMP activated Mr32kDa phosphoprotein (DARPP-32) is a central signaling proteins in neurotransmission. Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). Increasing evidence suggests a role for DARPP-32 and signal pathways related to cancer;

However, its role in ovarian cancer remains unclear. Using immunohistochemistry, expression of DARPP-32, PP1 and Cdk5 is determined in a large cohort of primary tumors from ovarian cancer patients (n = 428, 445 and 434 respectively) to evaluate the relationship between clinical outcome and clinicopathological criteria.

Low cytoplasmic and nuclear DARPP-32 expression was associated with a shorter overall patient survival and progression-free survival (P = 0.001, 0.001, 0.004 and 0.037 respectively). Low nuclear and cytoplasmic DARPP-32 expression remained significantly associated with overall survival in multivariate Cox regression (P = 0.045, hazard ratio (HR) = 0.734, 95% confidence interval (CI) = 0.542 to 0.993 and P = 0.001, HR = 0.494, 95% CI = 0.325 to 0.749, respectively).

cytoplasmic and nuclear high PP1 expression was associated with a shorter overall patient survival and expression of cytoplasmic PP1 high with progression-free survival shorter (P = 0.005, 0.033, and 0.037, respectively). Cdk5 high expression was associated with progression-free survival shorter (P = 0.006). These data demonstrate the role of DARPP-32 and related kinase signaling as a prognostic marker in ovarian cancer clinical utility.

Dopamine and cAMP-regulated phospho<em>protein</em> 32kDa (DARPP-32), <em>protein</em> <em>phosphatase</em>-<em>1</em> and cyclin-dependent kinase 5 expression in ovarian cancer
Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase1 and cyclin-dependent kinase 5 expression in ovarian cancer

Protein phosphatase one alpha Increase glucocorticoid receptor activity by a mechanism that involves phosphorylation of serine-2 one one < / em>

By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. A disturbed regulation of glucocorticoid action has been associated with various disorders. Thus, an explanation of the underlying signaling pathway is important for understanding the mechanisms of glucocorticoid impaired function and contribute to disease.

This study found an increase in excess GR transcriptional activity of protein phosphatase 1 alpha (PP1α) in HEK-293 cells and a decrease in the expression levels of GR-responsive gene knockdown following PP1α model A549 cells endogenously. Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3).

Thus, this study identified PP1α as a novel post-translational activator of GR signaling, indicating that PP1α function disorders can lead to disorders glucocorticoid action and thereby contribute to diseases.Ewing sarcoma (ES) is a pediatric malignant bone and soft tissue tumors. Patients with metastatic ES have dismal outcomes were not improved in decades. The major challenge in the treatment of metastatic ES is the lack of specific targets and rational combination therapy.

PPP1CA antibody

10R-1069 100 ul
EUR 379.2
Description: Mouse monoclonal PPP1CA antibody

PPP1CA Antibody

BF0683 200ul
EUR 540

PPP1CA Antibody

AF6638 100ul
EUR 420

PPP1CA antibody

70R-2013 50 ug
EUR 560.4
Description: Rabbit polyclonal PPP1CA antibody raised against the N terminal of PPP1CA

PPP1CA Antibody

32649-100ul 100ul
EUR 302.4

PPP1CA Antibody

ABD6907 100 ug
EUR 525.6

PPP1CA Antibody

DF6907 200ul
EUR 420

PPP1CA Antibody

DF2991 200ul
EUR 420

PPP1CA Antibody

1-CSB-PA030161
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

PPP1CA Antibody

CSB-PA018503KA01HU- each
EUR 402
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PPP1CA Antibody

CSB-PA018503KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PPP1CA Antibody

1-CSB-PA018503LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

PPP1CA/PPP1CB Antibody

DF2954 200ul
EUR 420

PPP1CA Rabbit pAb

A12468-100ul 100 ul
EUR 369.6

PPP1CA Rabbit pAb

A12468-200ul 200 ul
EUR 550.8

PPP1CA Rabbit pAb

A12468-20ul 20 ul
EUR 219.6

PPP1CA Rabbit pAb

A12468-50ul 50 ul
EUR 267.6

PPP1CA + 1CB Antibody

20-abx217900
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

PPP1CA + 1CB Antibody

45032-100ul 100ul
EUR 302.4

PPP1CA + 1CB Antibody

45032-50ul 50ul
EUR 224.4

PPP1CA + 1CB Antibody

ABD2954 100 ug
EUR 525.6

PPP1CA cloning plasmid

CSB-CL018503HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the PPP1CA gene.

PPP1CA Blocking Peptide

BF0683-BP 1mg
EUR 234

PPP1CA Blocking Peptide

33R-6411 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PPP1CA antibody, catalog no. 70R-2013

PPP1CA Blocking Peptide

DF6907-BP 1mg
EUR 234

Human Recombinant PPP1CA

6370-10 each
EUR 483.6

PPP1CA Monoclonal Antibody

27087-100ul 100ul
EUR 302.4

PPP1CA Monoclonal Antibody

27087-50ul 50ul
EUR 224.4

PPP1CA Protein (Recombinant)

20-abx073956
  • EUR 276.00
  • EUR 1930.80
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

PPP1CA Conjugated Antibody

C32649 100ul
EUR 476.4

PPP1CA protein (His tag)

80R-1935 10 ug
EUR 386.4
Description: Recombinant human PPP1CA protein

Mouse Ppp1ca ELISA KIT

ELI-36183m 96 Tests
EUR 1038

Human PPP1CA ELISA Kit

ELA-E9568h 96 Tests
EUR 988.8

PPP1CA ELISA KIT|Human

EF006522 96 Tests
EUR 826.8

Human PPP1CA ELISA KIT

ELI-16516h 96 Tests
EUR 988.8

Bovine PPP1CA ELISA KIT

ELI-45373b 96 Tests
EUR 1113.6

Canine PPP1CA ELISA KIT

ELI-21782d 96 Tests
EUR 1113.6

Rat PPP1CA shRNA Plasmid

20-abx984590
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human PPP1CA shRNA Plasmid

20-abx953684
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse PPP1CA shRNA Plasmid

20-abx972168
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

PPP1CA + 1CB Blocking Peptide

DF2954-BP 1mg
EUR 234

PPP1CA + 1CB Conjugated Antibody

C45032 100ul
EUR 476.4

PPP1CA Antibody, HRP conjugated

1-CSB-PA018503LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PPP1CA Recombinant Protein (Rat)

RP221681 100 ug Ask for price

PPP1CA Antibody, FITC conjugated

1-CSB-PA018503LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PPP1CA Recombinant Protein (Mouse)

RP163841 100 ug Ask for price

PPP1CA Recombinant Protein (Human)

RP024331 100 ug Ask for price

Ppp1ca ORF Vector (Rat) (pORF)

ORF073895 1.0 ug DNA
EUR 607.2

PPP1CA Antibody, Biotin conjugated

1-CSB-PA018503LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1CA. Recognizes PPP1CA from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PPP1CA ORF Vector (Human) (pORF)

ORF008111 1.0 ug DNA
EUR 114

Ppp1ca ORF Vector (Mouse) (pORF)

ORF054615 1.0 ug DNA
EUR 607.2

PPP1CA Conjugated Monoclonal Antibody

C27087 100ul
EUR 476.4

PPP1CA ELISA Kit (Dog) (OKEH08782)

OKEH08782 96 Wells
EUR 1420.8
Description: Description of target: ;Species reactivity: Dog;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity:

PPP1CA ELISA Kit (Rat) (OKEH05943)

OKEH05943 96 Wells
EUR 872.4
Description: Description of target: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.171 ng/mL

PPP1CA ELISA Kit (Human) (OKEH01979)

OKEH01979 96 Wells
EUR 872.4
Description: Description of target: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.055 ng/mL

PPP1CA ELISA Kit (Mouse) (OKEH04977)

OKEH04977 96 Wells
EUR 872.4
Description: Description of target: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.17 ng/mL

PPP1CA ELISA Kit (Bovine) (OKEH06691)

OKEH06691 96 Wells
EUR 934.8
Description: Description of target: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy.;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Competitive ELISA;Sensitivity: 0.25 ng/mL

Monoclonal PPP1CA Antibody, Clone: 5E9

AMM02873G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PPP1CA. The antibodies are raised in Mouse and are from clone 5E9. This antibody is applicable in WB, E

Ppp1ca 3'UTR GFP Stable Cell Line

TU166799 1.0 ml Ask for price

PPP1CA 3'UTR GFP Stable Cell Line

TU068618 1.0 ml
EUR 1672.8

Ppp1ca 3'UTR GFP Stable Cell Line

TU266644 1.0 ml Ask for price

Ppp1ca sgRNA CRISPR Lentivector set (Rat)

K7563101 3 x 1.0 ug
EUR 406.8

PPP1CA sgRNA CRISPR Lentivector set (Human)

K1701701 3 x 1.0 ug
EUR 406.8

Ppp1ca sgRNA CRISPR Lentivector set (Mouse)

K3345601 3 x 1.0 ug
EUR 406.8

PPP1CA Protein Vector (Rat) (pPM-C-HA)

PV295580 500 ng
EUR 723.6

PPP1CA Protein Vector (Rat) (pPB-C-His)

PV295578 500 ng
EUR 723.6

PPP1CA Protein Vector (Rat) (pPB-N-His)

PV295579 500 ng
EUR 723.6

PPP1CA Protein Vector (Rat) (pPM-C-His)

PV295581 500 ng
EUR 723.6

PPP1CA Protein Vector (Human) (pPM-C-HA)

PV032443 500 ng
EUR 394.8

PPP1CA Protein Vector (Mouse) (pPM-C-HA)

PV218460 500 ng
EUR 723.6

PPP1CA Protein Vector (Human) (pPB-C-His)

PV032441 500 ng
EUR 394.8

PPP1CA Protein Vector (Human) (pPB-N-His)

PV032442 500 ng
EUR 394.8

PPP1CA Protein Vector (Human) (pPM-C-His)

PV032444 500 ng
EUR 394.8

PPP1CA Protein Vector (Mouse) (pPB-C-His)

PV218458 500 ng
EUR 723.6

PPP1CA Protein Vector (Mouse) (pPB-N-His)

PV218459 500 ng
EUR 723.6

PPP1CA Protein Vector (Mouse) (pPM-C-His)

PV218461 500 ng
EUR 723.6

Ppp1ca 3'UTR Luciferase Stable Cell Line

TU116799 1.0 ml Ask for price

PPP1CA 3'UTR Luciferase Stable Cell Line

TU018618 1.0 ml
EUR 1672.8

Ppp1ca 3'UTR Luciferase Stable Cell Line

TU216644 1.0 ml Ask for price

Ppp1ca sgRNA CRISPR Lentivector (Rat) (Target 1)

K7563102 1.0 ug DNA
EUR 184.8

Ppp1ca sgRNA CRISPR Lentivector (Rat) (Target 2)

K7563103 1.0 ug DNA
EUR 184.8

Ppp1ca sgRNA CRISPR Lentivector (Rat) (Target 3)

K7563104 1.0 ug DNA
EUR 184.8

PPP1CA sgRNA CRISPR Lentivector (Human) (Target 1)

K1701702 1.0 ug DNA
EUR 184.8

PPP1CA sgRNA CRISPR Lentivector (Human) (Target 2)

K1701703 1.0 ug DNA
EUR 184.8

PPP1CA sgRNA CRISPR Lentivector (Human) (Target 3)

K1701704 1.0 ug DNA
EUR 184.8

Ppp1ca sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3345602 1.0 ug DNA
EUR 184.8

Ppp1ca sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3345603 1.0 ug DNA
EUR 184.8

Ppp1ca sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3345604 1.0 ug DNA
EUR 184.8

Recombinant Human PPP1CA Protein, His, E.coli-1ug

QP10835-1ug 1ug
EUR 186

Recombinant Human PPP1CA Protein, His, E.coli-5ug

QP10835-5ug 5ug
EUR 241.2

Recombinant Human PPP1CA Protein, His, E.coli-50ug

QP10835-50ug 50ug
EUR 1513.2

PPP1CA Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV690163 1.0 ug DNA
EUR 616.8

PPP1CA Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV690167 1.0 ug DNA
EUR 616.8

PPP1CA Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV690168 1.0 ug DNA
EUR 616.8

Protein Phosphatase 1 Catalytic Subunit Alpha (PPP1CA) Antibody

abx159655-100ul 100 ul
EUR 560.4

Protein Phosphatase 1 Catalytic Subunit Alpha (PPP1CA) Antibody

abx159656-100ul 100 ul
EUR 560.4

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K7563105 3 x 1.0 ug
EUR 451.2

PPP1CA sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1701705 3 x 1.0 ug
EUR 451.2

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3345605 3 x 1.0 ug
EUR 451.2

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Antibody

20-abx131494
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1CA) Antibody

20-abx329060
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K7563106 1.0 ug DNA
EUR 200.4

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K7563107 1.0 ug DNA
EUR 200.4

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K7563108 1.0 ug DNA
EUR 200.4

Recombinant Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca)

4-RPC198Hu01
  • EUR 421.06
  • EUR 236.40
  • EUR 1248.96
  • EUR 496.32
  • EUR 872.64
  • EUR 357.60
  • EUR 2942.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Protein Phosphatase 1, Catalytic Subunit Alpha Isoform expressed in: E.coli

PPP1CA sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1701706 1.0 ug DNA
EUR 200.4

PPP1CA sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1701707 1.0 ug DNA
EUR 200.4

PPP1CA sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1701708 1.0 ug DNA
EUR 200.4

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3345606 1.0 ug DNA
EUR 200.4

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3345607 1.0 ug DNA
EUR 200.4

Ppp1ca sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3345608 1.0 ug DNA
EUR 200.4

PPP1CA Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV690164 1.0 ug DNA
EUR 616.8

Monoclonal PPP1CA / PP1-Alpha Antibody (aa30-299, clone 4G3), Clone: 4G3

AMR09472G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human PPP1CA / PP1-Alpha (aa30-299, clone 4G3). The antibodies are raised in Mouse and are from clone 4G3. This antibody is applicable in WB and IHC-P, E

PPP1CA Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV690165 1.0 ug DNA
EUR 686.4

PPP1CA Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV690166 1.0 ug DNA
EUR 686.4

Human Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Protein

20-abx168833
  • EUR 594.00
  • EUR 292.80
  • EUR 1696.80
  • EUR 693.60
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Dog Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

1-CSB-EP840958DO
  • EUR 524.40
  • EUR 285.60
  • EUR 1852.80
  • EUR 783.60
  • EUR 1234.80
  • EUR 355.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Dog Serine/threonine-protein phosphatase PP1-alpha catalytic subunit(PPP1CA) expressed in E.coli

PPP1CA Protein Phosphatase 1, Catalytic Subunit Alpha Human Recombinant Protein

PROTP62136 Regular: 5ug
EUR 380.4
Description: PPP1CA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 350 amino acids (1-330 a.a) and having a molecular mass of 39.7kDa.;PPP1CA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody

abx117243-100ug 100 ug
EUR 560.4

Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody

20-abx001796
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody

abx011880-100ul 100 ul
EUR 493.2

Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody

20-abx302367
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody (HRP)

20-abx317114
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody (FITC)

20-abx317115
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serine/threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit (PPP1CA) Antibody (Biotin)

20-abx317116
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Cow Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) ELISA Kit

abx521210-96tests 96 tests
EUR 1093.2

Dog Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) ELISA Kit

abx521211-96tests 96 tests
EUR 1093.2

Rat Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) ELISA Kit

abx521214-96tests 96 tests
EUR 801.6

Rat Ppp1ca/ Serine/threonine-protein phosphatase PP1-alpha catalytic subunit ELISA Kit

E0786Ra 1 Kit
EUR 775.2

Human Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) ELISA Kit

abx251856-96tests 96 tests
EUR 801.6

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform Phospho-Thr320 (PPP1CA pT320) Antibody

20-abx326424
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) ELISA Kit

abx521213-96tests 96 tests
EUR 801.6

Bovine PPP1CA/ Serine/threonine-protein phosphatase PP1-alpha catalytic subunit ELISA Kit

E0216Bo 1 Kit
EUR 860.4

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig)

4-PAC198Hu01
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca)

Human PPP1CA(Serine/threonine-protein phosphatase PP1-alpha catalytic subunit) ELISA Kit

EH2488 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Mouse Ppp1ca/ Serine/threonine-protein phosphatase PP1-alpha catalytic subunit ELISA Kit

E1181Mo 1 Kit
EUR 758.4

Human PPP1CA/ Serine/threonine-protein phosphatase PP1-alpha catalytic subunit ELISA Kit

E2011Hu 1 Kit
EUR 726

ELISA kit for Mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

KTE70703-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

KTE70703-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

KTE70703-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig), APC

4-PAC198Hu01-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca). This antibody is labeled with APC.

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig), Cy3

4-PAC198Hu01-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca). This antibody is labeled with Cy3.

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig), FITC

4-PAC198Hu01-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca). This antibody is labeled with FITC.

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig), HRP

4-PAC198Hu01-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca). This antibody is labeled with HRP.

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig), PE

4-PAC198Hu01-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca). This antibody is labeled with PE.

Anti-PPP1CA+PPP1CB Rabbit Monoclonal Antibody

M02801 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal PPP1CA+PPP1CB Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig), Biotinylated

4-PAC198Hu01-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca). This antibody is labeled with Biotin.

Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca) Polyclonal Antibody (Human, Pig), APC-Cy7

4-PAC198Hu01-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Protein Phosphatase 1, Catalytic Subunit Alpha Isoform (PPP1Ca). This antibody is labeled with APC-Cy7.

Ppp3ca/ Rat Ppp3ca ELISA Kit

ELI-43553r 96 Tests
EUR 1063.2

Ppp2ca/ Rat Ppp2ca ELISA Kit

ELI-12722r 96 Tests
EUR 1063.2

PPP2CA siRNA

20-abx929536
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PPP2CA siRNA

20-abx929537
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

We recently discovered a protein phosphatase 1 regulatory subunit 1A (PPP1R1A) specifically highly expressed in ES and promote tumor growth and metastasis in ES. In the current investigation, we showed that PPP1R1A regulate ES cell growth cycle at the G1 / S phase to down-regulate the cell cycle inhibitor p21Cip1 and p27KIP1, which leads to retinoblastoma (Rb) protein hyperphosphorylation. In addition, we show that the normal transcription PPP1R1A promotes histone genes during cell cycle progression.

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