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Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids

Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids
Posted by Karen

hepatitis B virus (HBV) DNA replicates its genome through DNA virus prime reverse transcription polymerase themselves of pre-genomic RNA in the nucleocapsid core protein is assembled by 120 (Cp) dimer. The carboxyl-terminal arginine-rich domain (CTD) Cp play an important role in selective packaging of viral DNA polymerase-pregenomic (pg) RNA into the nucleocapsid complex. Earlier research has suggested that CTD initially phosphorylated at multiple sites to facilitate the packaging of viral RNA and then dephosphorylated with regard to viral DNA synthesis and secretion of DNA containing virions.

However, our recent studies suggest that Cp is hyper-phosphorylated as a free dimer and dephosphorylation associated with pgRNA encapsidation. Here, we provide genetic and biochemical evidence of more extensive supporting Cp dephosphorylation not take place during the assembly pgRNA containing the nucleocapsid, but not empty capsids. In addition, we found that the cellular protein phosphatase 1 (PP1) is necessary for dephosphorylation and packaging pgRNA Cp.

Interestingly, PP1 catalytic subunit α and β are packed into pgRNA containing the nucleocapsid, but not empty capsids, and the treatment of HBV-replicating cells with core protein allosteric modulator (CpAMs) promoted empty capsid assembly and encapsidation repeal of PP1 α and β. Our study thus identified PP1 as the host cellular factors that are co-packaged into the nucleocapsid HBV, and plays an important role in selective packaging of viral DNA-polymerase-catalyzed pgRNA complex via Cp dephosphorylation.

<em>Protein</em> <em>phosphatase</em> <em>1</em> catalyzes HBV core <em>protein</em> dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids
Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids

A novel protein tyrosine phosphatase one B inhibitor-geranylated flavonoids from mulberry leaves ameliorates insulin resistance

Mulberry leaf vegetables are common to a variety of beneficial effects, such as hypoglycemic activity. However, the underlying mechanism of the hypoglycemic effect that has not been revealed fully. In this study, two flavonoid derivatives isolated from mulberry leaves, a new geranylated flavonoid compounds (1) and a structural analogue (2). Structures 1 and 2 are described using spectroscopic analysis.

To study the properties of the hypoglycemic potential of this compound, the effect of the regulation of protein tyrosine phosphatase 1B (PTP1B) was investigated. Compared with oleanolic acid, compounds 1 and 2 showed a significant inhibitory activity (IC50 = 4.53 ± 0.31 and 10.53 ± 1.76 M) against PTP1B, a positive control (IC50 = 7.94 ± 0.76 M). molecular docking to predict the binding sites 1 and PTP1B.

In insulin resistance HepG2 cells, first promoted glucose consumption with a dose-dependent manner. Furthermore, western blot and PCR analysis showed that one may regulate the consumption of glucose by PTP1B / IRS / PI3K / AKT pathways. In conclusion, the mulberry leaf flavonoids inhibite geranylated PTP1B and increase the consumption of glucose in insulin-resistant cells. These findings provide an important basis for the use of mulberry leaf flavonoids as a dietary supplement to regulate glucose metabolism.

PTPRC Antibody

CSB-PA019049KA01HU-
EUR 335
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PTPRC Antibody

CSB-PA019049KA01HU-100ul 100ul
EUR 389
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PTPRC Antibody

1-CSB-PA868166
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:100-1:300

PTPRC Antibody

1-CSB-PA480713
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

PTPRC Antibody

32607-100ul 100ul
EUR 252

PTPRC siRNA

20-abx930397
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PTPRC siRNA

20-abx930398
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PTPRC Antibody

ABD6839 100 ug
EUR 438

PTPRC Antibody

DF6839 200ul
EUR 304
Description: PTPRC Antibody detects endogenous levels of total PTPRC.

Anti-PTPRC antibody

STJ25231 100 µl
EUR 277
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Anti-PTPRC antibody

STJ25232 100 µl
EUR 277
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Anti-PTPRC antibody

STJ25235 100 µl
EUR 277
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Anti-PTPRC antibody

STJ110946 100 µl
EUR 393
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

PTPRC Rabbit pAb

A0372-100ul 100 ul
EUR 308

PTPRC Rabbit pAb

A0372-200ul 200 ul
EUR 459

PTPRC Rabbit pAb

A0372-20ul 20 ul
EUR 183

PTPRC Rabbit pAb

A0372-50ul 50 ul
EUR 223

PTPRC Rabbit pAb

A0373-100ul 100 ul
EUR 384

PTPRC Rabbit pAb

A0373-200ul 200 ul Ask for price

PTPRC Rabbit pAb

A0373-20ul 20 ul Ask for price

PTPRC Rabbit pAb

A0373-50ul 50 ul
EUR 265

PTPRC Protein (Recombinant)

20-abx073990
  • EUR 1609.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg

PTPRC Rabbit pAb

A2115-100ul 100 ul
EUR 308

PTPRC Rabbit pAb

A2115-200ul 200 ul
EUR 459

PTPRC Rabbit pAb

A2115-20ul 20 ul
EUR 183

PTPRC Rabbit pAb

A2115-50ul 50 ul
EUR 223

PTPRC (pS1007) Antibody

abx333331-100ul 100 ul
EUR 467

PTPRC Conjugated Antibody

C32607 100ul
EUR 397

PTPRC Blocking Peptide

DF6839-BP 1mg
EUR 195

Anti-PTPRC (3D3)

YF-MA20406 100 ug
EUR 363
Description: Mouse monoclonal to PTPRC

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC042026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF405S conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC042026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF405S conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC432026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF543 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC432026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF543 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC472026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF647 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC472026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF647 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCAP2026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCAP2026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC802026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC802026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC812026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC812026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC682026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF568 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC682026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF568 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC702026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF770 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC702026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF770 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC882026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF488A conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC882026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF488A conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC612026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF660R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC612026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF660R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC942026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF594 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC942026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF594 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCA2026-250 250uL
EUR 394
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), APC conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNUB2026-100 100uL
EUR 264
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Concentration: 0.2mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNUB2026-50 50uL
EUR 405
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), 1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNUB2026-500 500uL
EUR 513
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Concentration: 0.2mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCH2026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCH2026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC052026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF405M conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC052026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF405M conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCP2026-250 250uL
EUR 394
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), PerCP conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCR2026-250 250uL
EUR 394
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), RPE conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC402026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF640R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC402026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF640R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCB2026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Biotin conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCB2026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Biotin conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC552026-100 100uL
EUR 233
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF555 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC552026-500 500uL
EUR 545
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF555 conjugate, Concentration: 0.1mg/mL

Phospho-PTPRC (S1007) Antibody

1-CSB-PA040112
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-PTPRC (S1007). Recognizes Phospho-PTPRC (S1007) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/5000

Phospho-PTPRC (Ser1007) Antibody

CSB-PA446974-
EUR 335
Description: A polyclonal antibody against Phospho-PTPRC (Ser1007). Recognizes Phospho-PTPRC (Ser1007) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-PTPRC (Ser1007) Antibody

CSB-PA446974-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-PTPRC (Ser1007). Recognizes Phospho-PTPRC (Ser1007) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Anti-CD45/PTPRC Antibody

PA1596 100ug/vial
EUR 334

Anti-CD45/PTPRC Antibody

PB9096 100ug/vial
EUR 334

Anti-CD45/PTPRC Antibody

PB9785 100ug/vial
EUR 334

Anti-CD45/PTPRC Antibody

A00555-2 100ug/vial
EUR 294

CD45RA(PTPRC/818) Antibody

BNC040818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC040818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC041131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC041131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), CF405S conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC041132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), CF405S conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC041132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), CF405S conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC041147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), CF405S conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC041147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC041148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC041148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), CF405S conjugate, Concentration: 0.1mg/mL

Rat PTPRC shRNA Plasmid

20-abx984608
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human PTPRC shRNA Plasmid

20-abx953910
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

CD45RA(PTPRC/818) Antibody

BNC470818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC470818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC471131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC471131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), CF647 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC471132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), CF647 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC471132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), CF647 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC471147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), CF647 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC471147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC471148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC471148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNCAP0818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNCAP0818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCAP1131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCAP1131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCAP1132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCAP1132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCAP1147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCAP1147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCAP1148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCAP1148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNCB0818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNCB0818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC810818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC810818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC811131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC811131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC811132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC811132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC811147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC811147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC811148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC811148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC681131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC681131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), CF568 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC681132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), CF568 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC681132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), CF568 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC681147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), CF568 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC681147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC681148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC681148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC700818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC700818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC701131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC701131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC701132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC701132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC701147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC701147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC701148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC701148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC880818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC880818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC881131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC881131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), CF488A conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC881132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), CF488A conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC881132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), CF488A conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC881147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), CF488A conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC881147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC881148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC881148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC610818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC610818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC611131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC611131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC611132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC611132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC611147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC611147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC611148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC611148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC680818-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/818), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNC680818-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/818), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNCA0818-250 250uL
EUR 383
Description: Primary antibody against CD45RA(PTPRC/818), APC conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCA1131-250 250uL
EUR 383
Description: Primary antibody against CD45RA(PTPRC/1131), APC conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCA1132-250 250uL
EUR 383
Description: Primary antibody against CD45RB(PTPRC/1132), APC conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCA1147-250 250uL
EUR 383
Description: Primary antibody against CD45RB(PTPRC/1147), APC conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCA1148-250 250uL
EUR 383
Description: Primary antibody against CD45RA(PTPRC/1148), APC conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNUB1147-100 100uL
EUR 209
Description: Primary antibody against CD45RB(PTPRC/1147), Concentration: 0.2mg/mL

CD45RB(PTPRC/1147) Antibody

BNUB1147-500 500uL
EUR 458
Description: Primary antibody against CD45RB(PTPRC/1147), Concentration: 0.2mg/mL

CD45RA(PTPRC/1148) Antibody

BNUB1148-100 100uL
EUR 209
Description: Primary antibody against CD45RA(PTPRC/1148), Concentration: 0.2mg/mL

CD45RA(PTPRC/1148) Antibody

BNUB1148-500 500uL
EUR 458
Description: Primary antibody against CD45RA(PTPRC/1148), Concentration: 0.2mg/mL

CD45RA(PTPRC/818) Antibody

BNUM0818-50 50uL
EUR 395
Description: Primary antibody against CD45RA(PTPRC/818), 1mg/mL

CD45RA(PTPRC/1131) Antibody

BNUM1131-50 50uL
EUR 395
Description: Primary antibody against CD45RA(PTPRC/1131), 1mg/mL

CD45RB(PTPRC/1132) Antibody

BNUM1132-50 50uL
EUR 395
Description: Primary antibody against CD45RB(PTPRC/1132), 1mg/mL

CD45RB(PTPRC/1147) Antibody

BNUM1147-50 50uL
EUR 395
Description: Primary antibody against CD45RB(PTPRC/1147), 1mg/mL

CD45RA(PTPRC/1148) Antibody

BNUM1148-50 50uL
EUR 395
Description: Primary antibody against CD45RA(PTPRC/1148), 1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCH1131-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1131), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCH1131-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1131), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCH1132-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1132), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCH1132-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1132), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCH1147-100 100uL
EUR 199
Description: Primary antibody against CD45RB(PTPRC/1147), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCH1147-500 500uL
EUR 544
Description: Primary antibody against CD45RB(PTPRC/1147), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCH1148-100 100uL
EUR 199
Description: Primary antibody against CD45RA(PTPRC/1148), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCH1148-500 500uL
EUR 544
Description: Primary antibody against CD45RA(PTPRC/1148), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/818) Antibody

BNCP0818-250 250uL
EUR 383
Description: Primary antibody against CD45RA(PTPRC/818), PerCP conjugate, Concentration: 0.1mg/mL


ten different cDNA encoding five different protein phosphatase 1 (ppp1) were cloned from Nilaparvata lugens. NlPPP1α and NlPPP1β highly conserved while NlPPP1-Y, NlPPP1-Y1 and Y2 NlPPP1 low-conserved between insects. NlPPP1α and NlPPP1β exhibited expression everywhere, while NlPPP1-Y, NlPPP1-Y1, and NlPPP1-Y2 are clearly detectable from instar nymphs 4 to adult stage of development in males, mainly detected in the internal reproductive organs and body fat than men -laki. nymphs injection with dsRNA of NlPPP1α or NlPPP1β able to reduce the expression of target genes in the range of 71.5 to 91.0%, pushing the maximum mortality rate of 95.2% or 97.2% on day 10 after the injection and eclosion rate fell 65, 5 to 100.0%.

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