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Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids

Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids
Posted by Karen

hepatitis B virus (HBV) DNA replicates its genome through DNA virus prime reverse transcription polymerase themselves of pre-genomic RNA in the nucleocapsid core protein is assembled by 120 (Cp) dimer. The carboxyl-terminal arginine-rich domain (CTD) Cp play an important role in selective packaging of viral DNA polymerase-pregenomic (pg) RNA into the nucleocapsid complex. Earlier research has suggested that CTD initially phosphorylated at multiple sites to facilitate the packaging of viral RNA and then dephosphorylated with regard to viral DNA synthesis and secretion of DNA containing virions.

However, our recent studies suggest that Cp is hyper-phosphorylated as a free dimer and dephosphorylation associated with pgRNA encapsidation. Here, we provide genetic and biochemical evidence of more extensive supporting Cp dephosphorylation not take place during the assembly pgRNA containing the nucleocapsid, but not empty capsids. In addition, we found that the cellular protein phosphatase 1 (PP1) is necessary for dephosphorylation and packaging pgRNA Cp.

Interestingly, PP1 catalytic subunit α and β are packed into pgRNA containing the nucleocapsid, but not empty capsids, and the treatment of HBV-replicating cells with core protein allosteric modulator (CpAMs) promoted empty capsid assembly and encapsidation repeal of PP1 α and β. Our study thus identified PP1 as the host cellular factors that are co-packaged into the nucleocapsid HBV, and plays an important role in selective packaging of viral DNA-polymerase-catalyzed pgRNA complex via Cp dephosphorylation.

<em>Protein</em> <em>phosphatase</em> <em>1</em> catalyzes HBV core <em>protein</em> dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids
Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids

A novel protein tyrosine phosphatase one B inhibitor-geranylated flavonoids from mulberry leaves ameliorates insulin resistance

Mulberry leaf vegetables are common to a variety of beneficial effects, such as hypoglycemic activity. However, the underlying mechanism of the hypoglycemic effect that has not been revealed fully. In this study, two flavonoid derivatives isolated from mulberry leaves, a new geranylated flavonoid compounds (1) and a structural analogue (2). Structures 1 and 2 are described using spectroscopic analysis.

To study the properties of the hypoglycemic potential of this compound, the effect of the regulation of protein tyrosine phosphatase 1B (PTP1B) was investigated. Compared with oleanolic acid, compounds 1 and 2 showed a significant inhibitory activity (IC50 = 4.53 ± 0.31 and 10.53 ± 1.76 M) against PTP1B, a positive control (IC50 = 7.94 ± 0.76 M). molecular docking to predict the binding sites 1 and PTP1B.

In insulin resistance HepG2 cells, first promoted glucose consumption with a dose-dependent manner. Furthermore, western blot and PCR analysis showed that one may regulate the consumption of glucose by PTP1B / IRS / PI3K / AKT pathways. In conclusion, the mulberry leaf flavonoids inhibite geranylated PTP1B and increase the consumption of glucose in insulin-resistant cells. These findings provide an important basis for the use of mulberry leaf flavonoids as a dietary supplement to regulate glucose metabolism.

PTPRC

MBS8565035-01mL 0.1mL
EUR 345

PTPRC

MBS8565035-01mLAF405L 0.1mL(AF405L)
EUR 565

PTPRC

MBS8565035-01mLAF405S 0.1mL(AF405S)
EUR 565

PTPRC

MBS8565035-01mLAF610 0.1mL(AF610)
EUR 565

PTPRC

MBS8565035-01mLAF635 0.1mL(AF635)
EUR 565

PTPRC

MBS8563192-01mLAF405L 0.1mL(AF405L)
EUR 565

PTPRC

MBS8563192-01mLAF405S 0.1mL(AF405S)
EUR 565

PTPRC

MBS8563192-01mLAF610 0.1mL(AF610)
EUR 565

PTPRC

MBS8563192-01mLAF635 0.1mL(AF635)
EUR 565

PTPRC

MBS8563192-02mL 0.2mL
EUR 345

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC802026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC802026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC812026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC812026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF680R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC052026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF405M conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC052026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF405M conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC432026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF543 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC432026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF543 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC552026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF555 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC552026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF555 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC702026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF770 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC702026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF770 conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC612026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF660R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNC612026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF660R conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCH2026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCH2026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCP2026-250 250uL
EUR 472.8
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), PerCP conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCR2026-250 250uL
EUR 472.8
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), RPE conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCA2026-250 250uL
EUR 472.8
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), APC conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCAP2026-100 100uL
EUR 279.6
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNCAP2026-500 500uL
EUR 654
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R) Antibody

BNUB2026-50 50uL
EUR 486
Description: Primary antibody against CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), 1mg/mL

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), 1mg/mL

BNUM2027-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), 0.2mg/mL

BNUB2027-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), 0.2mg/mL

BNUB2027-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), 1mg/mL

BNUM2026-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), 0.2mg/mL

BNUB2026-100 100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), 0.2mg/mL

BNUB2026-500 500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

PTPRC siRNA

20-abx930397
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  • Ask for price
  • 15 nmol
  • 30 nmol

PTPRC siRNA

20-abx930398
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

PTPRC Antibody

32607-100ul 100ul
EUR 302.4

PTPRC Antibody

E19-6839 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PTPRC Antibody

1-CSB-PA868166
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:100-1:300

PTPRC Antibody

CSB-PA019049KA01HU- each
EUR 402
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PTPRC Antibody

CSB-PA019049KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

PTPRC Antibody

E92115 100ul
EUR 255
Description: Available in various conjugation types.

PTPRC Antibody

E311064 200ul
EUR 275
Description: Available in various conjugation types.

PTPRC Antibody

1-CSB-PA010546
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

PTPRC Antibody

1-CSB-PA480713
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against PTPRC. Recognizes PTPRC from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

PTPRC Antibody

ABD6839 100ug
EUR 325

PTPRC Antibody

MBS7128708-005mL 0.05mL
EUR 190

PTPRC Antibody

MBS7128708-01mL 0.1mL
EUR 270

PTPRC Antibody

MBS7128708-5x01mL 5x0.1mL
EUR 1205

PTPRC Antibody

MBS7128709-005mL 0.05mL
EUR 190

PTPRC Antibody

MBS7128709-01mL 0.1mL
EUR 270

PTPRC Antibody

MBS7128709-5x01mL 5x0.1mL
EUR 1205

PTPRC Antibody

MBS7118797-005mg 0.05mg
EUR 150

PTPRC Antibody

MBS7118797-01mg 0.1mg
EUR 190

PTPRC Antibody

MBS7118797-5x01mg 5x0.1mg
EUR 845

PTPRC Antibody

MBS9401852-005mL 0.05mL
EUR 300

PTPRC Antibody

MBS9401852-01mL 0.1mL
EUR 390

PTPRC Antibody

MBS9401852-5x01mL 5x0.1mL
EUR 1610

PTPRC Antibody

MBS8516309-01mg 0.1mg
EUR 305

PTPRC Antibody

MBS8516309-01mLAF405L 0.1mL(AF405L)
EUR 465

PTPRC Antibody

MBS8516309-01mLAF405S 0.1mL(AF405S)
EUR 465

PTPRC Antibody

MBS8516309-01mLAF610 0.1mL(AF610)
EUR 465

PTPRC Antibody

MBS8516309-01mLAF635 0.1mL(AF635)
EUR 465

PTPRC Antibody

MBS8503990-01mL 0.1mL
EUR 325

PTPRC Antibody

MBS8503990-01mLAF405L 0.1mL(AF405L)
EUR 565

PTPRC Antibody

MBS8503990-01mLAF405S 0.1mL(AF405S)
EUR 565

PTPRC Antibody

MBS8503990-01mLAF610 0.1mL(AF610)
EUR 565

PTPRC Antibody

MBS8503990-01mLAF635 0.1mL(AF635)
EUR 565

PTPRC Antibody

MBS2527897-006mL 0.06mL
EUR 190

PTPRC Antibody

MBS2527897-012mL 0.12mL
EUR 265

PTPRC Antibody

MBS2527897-02mL 0.2mL
EUR 415

PTPRC Antibody

MBS2527897-5x02mL 5x0.2mL
EUR 1835

PTPRC Antibody

MBS9607492-01mL 0.1mL
EUR 260

PTPRC Antibody

MBS9607492-02mL 0.2mL
EUR 305

PTPRC Antibody

MBS9607492-5x02mL 5x0.2mL
EUR 1220

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF594 conjugate, 0.1mg/mL

BNC942027-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF594 conjugate, 0.1mg/mL

BNC942027-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF647 conjugate, 0.1mg/mL

BNC472027-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF647 conjugate, 0.1mg/mL

BNC472027-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF568 conjugate, 0.1mg/mL

BNC682027-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF568 conjugate, 0.1mg/mL

BNC682027-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF405S conjugate, 0.1mg/mL

BNC042027-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF405S conjugate, 0.1mg/mL

BNC042027-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF488A conjugate, 0.1mg/mL

BNC882027-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF488A conjugate, 0.1mg/mL

BNC882027-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF640R conjugate, 0.1mg/mL

BNC402027-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), CF640R conjugate, 0.1mg/mL

BNC402027-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), Biotin conjugate, 0.1mg/mL

BNCB2027-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker)(PTPRC/1147 + PTPRC/1460), Biotin conjugate, 0.1mg/mL

BNCB2027-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45RA(PTPRC/1131) Antibody

BNC811131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC811131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC811132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC811132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC811147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF680R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC811147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC811148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC811148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC801131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC801131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF680 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC801132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF680 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC801132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF680 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC801147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF680 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC801147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC801148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC801148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC431131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC431131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF543 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC431132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF543 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC431132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF543 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC431147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF543 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC431147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC431148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC431148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC051131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC051131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF405M conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC051132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF405M conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC051132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF405M conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC051147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF405M conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC051147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC051148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC051148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC551131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC551131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF555 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC551132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF555 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC551132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF555 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC551147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF555 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC551147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC551148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC551148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC701131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC701131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC701132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC701132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC701147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF770 conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC701147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC701148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC701148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC611131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNC611131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC611132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNC611132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC611147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF660R conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNC611147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC611148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNC611148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCP1131-250 250uL
EUR 459.6
Description: Primary antibody against CD45RA(PTPRC/1131), PerCP conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCP1132-250 250uL
EUR 459.6
Description: Primary antibody against CD45RB(PTPRC/1132), PerCP conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCP1147-250 250uL
EUR 459.6
Description: Primary antibody against CD45RB(PTPRC/1147), PerCP conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCP1148-250 250uL
EUR 459.6
Description: Primary antibody against CD45RA(PTPRC/1148), PerCP conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCR1131-250 250uL
EUR 459.6
Description: Primary antibody against CD45RA(PTPRC/1131), RPE conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCR1132-250 250uL
EUR 459.6
Description: Primary antibody against CD45RB(PTPRC/1132), RPE conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCR1147-250 250uL
EUR 459.6
Description: Primary antibody against CD45RB(PTPRC/1147), RPE conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCR1148-250 250uL
EUR 459.6
Description: Primary antibody against CD45RA(PTPRC/1148), RPE conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCA1131-250 250uL
EUR 459.6
Description: Primary antibody against CD45RA(PTPRC/1131), APC conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCA1132-250 250uL
EUR 459.6
Description: Primary antibody against CD45RB(PTPRC/1132), APC conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCA1147-250 250uL
EUR 459.6
Description: Primary antibody against CD45RB(PTPRC/1147), APC conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCA1148-250 250uL
EUR 459.6
Description: Primary antibody against CD45RA(PTPRC/1148), APC conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCH1131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCH1131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCH1132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCH1132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCH1147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCH1147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCH1148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCH1148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCAP1131-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1131), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1131) Antibody

BNCAP1131-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1131), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCAP1132-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1132), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1132) Antibody

BNCAP1132-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1132), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCAP1147-100 100uL
EUR 238.8
Description: Primary antibody against CD45RB(PTPRC/1147), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RB(PTPRC/1147) Antibody

BNCAP1147-500 500uL
EUR 652.8
Description: Primary antibody against CD45RB(PTPRC/1147), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCAP1148-100 100uL
EUR 238.8
Description: Primary antibody against CD45RA(PTPRC/1148), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(PTPRC/1148) Antibody

BNCAP1148-500 500uL
EUR 652.8
Description: Primary antibody against CD45RA(PTPRC/1148), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF594 conjugate, 0.1mg/mL

BNC942026-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF594 conjugate, 0.1mg/mL

BNC942026-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF647 conjugate, 0.1mg/mL

BNC472026-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF647 conjugate, 0.1mg/mL

BNC472026-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45 / LCA (Leucocyte Marker) (PTPRC/1783R + PTPRC/1975R), CF568 conjugate, 0.1mg/mL

BNC682026-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application


ten different cDNA encoding five different protein phosphatase 1 (ppp1) were cloned from Nilaparvata lugens. NlPPP1α and NlPPP1β highly conserved while NlPPP1-Y, NlPPP1-Y1 and Y2 NlPPP1 low-conserved between insects. NlPPP1α and NlPPP1β exhibited expression everywhere, while NlPPP1-Y, NlPPP1-Y1, and NlPPP1-Y2 are clearly detectable from instar nymphs 4 to adult stage of development in males, mainly detected in the internal reproductive organs and body fat than men -laki. nymphs injection with dsRNA of NlPPP1α or NlPPP1β able to reduce the expression of target genes in the range of 71.5 to 91.0%, pushing the maximum mortality rate of 95.2% or 97.2% on day 10 after the injection and eclosion rate fell 65, 5 to 100.0%.

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