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SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase1.

SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1.
Posted by Karen

Activation of mitogen-activated protein kinase phosphatase-1 (MKP-1), dual-specificity protein phosphatase, set the mitogen-activated protein kinase signaling. C-Jun N-terminal kinase (JNK) and p38 activated cisplatin-induced renal injury. However, changes in the expression of MKP-1 cisplatin-induced kidney injury and the effects of regulation sirtuin 2 (SIRT2), a nicotinamide adenine dinucleotide dependent deacetylase, the MKP-1 remains unknown.

To solve this problem, we use the constitution Sirt2 knockout (KO) mice, transgenic (TG) mice with increased expression of SIRT2 particularly in the proximal tubule epithelial cellsand wild-type (WT) mice. Cisplatin nephrotoxicity induced by intraperitoneal injection of cisplatin.MKP-1 expression in the kidney to decline after cisplatin treatment. Cisplatin-induced downregulation of MKP-1 KO mice Sirt2 reversed in the kidneys and then decreased in TG mice Sirt2 kidney.

We observed a similar phenomenon with SIRT2-knockdown or SIRT2-expressed in tubular epithelial cells. Phosphorylation of p38 and JNK, downstream signaling pathways MKP-1, is increased in WT mice after treatment with cisplatin kidney. Decrease SIRT2 suppressed cisplatin-induced phosphorylation of p38 and JNK in renal and tubular epithelial cells.

Excess of SIRT2 increase phosphorylation of p38 and JNK in renal and tubular epithelial cells. Acetylation of MKP-1 increased significantly in SIRT2-knockdown cells and a decrease in SIRT2-expressed cells after stimulation cisplatin. Sirt2 KO mice and Sirt2 TG mice showed improvement and aggravation of kidney injury, apoptosis, necroptosis and inflammation caused by cisplatin.Our data showed that SIRT2 associated with cisplatin-induced renal injury through regulation MKP-1 expression.

SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated <em>protein</em> kinase <em>phosphatase</em>-<em>1</em>.
SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase1.

Protein phosphatase one controls the activity of a balance between collective and singular mode of cell migration.

collective cell migration is central to many developmental and pathological processes. However, the collective mechanisms that keep cells together and coordinate the movement of some cells are poorly understood. Using a Drosophila Model border cell migration, we found that cell cohesion protein phosphatase 1 (PP1) activity collective control and migration.

Inhibition of PP1 causes cells to get round the border, which split off, and move it as single cell motility changes. We are proof that PP1 promoting appropriate levels of cadherin-catenin protein-complex at the intersection of the cells in the cluster to keep the cells along the border. Limiting PP1 actomyosin contractility advanced to the outskirts of the cluster rather than on the internal border cell contact that individual. We showed that the myosin phosphatase PP1 complex, which blocks non-muscle myosin II- (Myo-II) activity, cell shape and the boundary coordinates of cluster cohesion.

Given the high conservation of the PP1 complex, this study identifies collective PP1 as the main regulator of the single cell migration.
Protein phosphatase methylesterase 1 has been identified as a new gene that is upregulated in skeletal muscle in response to neurogenic atrophy in mice. Western blot analysis confirms that Ppme1 expressed during both muscle cell proliferation and differentiation.

PPP1R15A siRNA

20-abx929481
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  • 15 nmol
  • 30 nmol

PPP1R15A siRNA

20-abx929482
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  • 15 nmol
  • 30 nmol

PPP1R15A siRNA

20-abx904181
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  • 15 nmol
  • 30 nmol

PPP1R15A antibody

10R-7104 100 ul
EUR 758
Description: Mouse monoclonal PPP1R15A antibody

PPP1R15A antibody

10R-7105 100 ul
EUR 709
Description: Mouse monoclonal PPP1R15A antibody

PPP1R15A antibody

10R-7106 100 ul
EUR 709
Description: Mouse monoclonal PPP1R15A antibody

PPP1R15A Antibody

39948-100ul 100ul
EUR 468

PPP1R15A Antibody

E043273 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PPP1R15A Antibody

E307031b 100ug/200ul
EUR 275
Description: Available in various conjugation types.

PPP1R15A Antibody

43273 100ul
EUR 319

PPP1R15A Antibody

43273-100ul 100ul
EUR 302.4

PPP1R15A Antibody

1-CSB-PA018528GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against PPP1R15A. Recognizes PPP1R15A from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB

PPP1R15A Antibody

1-CSB-PA787946
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PPP1R15A. Recognizes PPP1R15A from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000

PPP1R15A Antibody

GWB-MW960F 50ug Ask for price

PPP1R15A Rabbit pAb

A16260-100ul 100 ul
EUR 369.6

PPP1R15A Rabbit pAb

A16260-200ul 200 ul
EUR 550.8

PPP1R15A Rabbit pAb

A16260-20ul 20 ul
EUR 219.6

PPP1R15A Rabbit pAb

A16260-50ul 50 ul
EUR 267.6

PPP1R15A cloning plasmid

CSB-CL018528HU-10ug 10ug
EUR 812.4
Description: A cloning plasmid for the PPP1R15A gene.

Ppp1r15a Antibody / Gadd34

RQ7322 100ug
EUR 419

PPP1R15A Polyclonal Antibody

E95590 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPP1R15A Polyclonal Antibody

E916260 100ul
EUR 225
Description: Available in various conjugation types.

PPP1R15A Polyclonal Antibody

E917117 100ul
EUR 225
Description: Available in various conjugation types.

PPP1R15A Conjugated Antibody

C43273 100ul
EUR 476.4

PPP1R15A Polyclonal Antibody

E-AB-19394-120uL 120uL
EUR 240
Description: Unconjugated

PPP1R15A Polyclonal Antibody

E-AB-19394-200uL 200uL
EUR 399
Description: Unconjugated

PPP1R15A Polyclonal Antibody

E-AB-19394-20uL 20uL
EUR 73
Description: Unconjugated

PPP1R15A Polyclonal Antibody

E-AB-19394-60uL 60uL
EUR 143
Description: Unconjugated

PPP1R15A Polyclonal Antibody

E-AB-91486-120uL 120uL
EUR 320
Description: Unconjugated

PPP1R15A Polyclonal Antibody

E-AB-91486-200uL 200uL
EUR 530
Description: Unconjugated

PPP1R15A Polyclonal Antibody

E-AB-91486-60uL 60uL
EUR 200
Description: Unconjugated

PPP1R15A Polyclonal Antibody

E-AB-91486-each each Ask for price
Description: Unconjugated

Human PPP1R15A ELISA KIT

ELI-43112h 96 Tests
EUR 988.8

Mouse Ppp1r15a ELISA KIT

ELI-43113m 96 Tests
EUR 1038

Bovine PPP1R15A ELISA KIT

ELI-19724b 96 Tests
EUR 1113.6

Rat PPP1R15A shRNA Plasmid

20-abx987671
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  • 150 µg
  • 300 µg

Human PPP1R15A shRNA Plasmid

20-abx958419
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  • 150 µg
  • 300 µg

Mouse PPP1R15A shRNA Plasmid

20-abx971639
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  • 150 µg
  • 300 µg

PPP1R15A (untagged)-Human protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A)

SC115045 10 µg Ask for price

PPP1R15A Recombinant Protein (Rat)

RP221720 100 ug Ask for price

OACD00845-1ML - PPP1R15A Antibody

OACD00845-1ML 1ml
EUR 649

OACD00846-1ML - PPP1R15A Antibody

OACD00846-1ML 1ml
EUR 729

PPP1R15A Recombinant Protein (Mouse)

RP163886 100 ug Ask for price

PPP1R15A Recombinant Protein (Human)

RP024352 100 ug Ask for price

PPP1R15A Rabbit Polyclonal Antibody

54166 100ul
EUR 439

OAGA05167-100UL - PPP1R15A Antibody

OAGA05167-100UL 100ul
EUR 369

OASA06175-100UG - PPP1R15A Antibody

OASA06175-100UG 0.1mg
EUR 649

OACD00845-100UL - PPP1R15A Antibody

OACD00845-100UL 100ul
EUR 199

OACD00846-100UL - PPP1R15A Antibody

OACD00846-100UL 100ul
EUR 209

PPP1R15A Rabbit Polyclonal Antibody

E307031 100ug/200ul
EUR 295
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PPP1R15A Rabbit Polyclonal Antibody

E10G05659 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PPP1R15A Rabbit Polyclonal Antibody

E10G12532 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Ppp1r15a (untagged) - Mouse protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), (10ug)

MC220161 10 µg Ask for price

PPP1R15A (GFP-tagged) - Human protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A)

RG200581 10 µg Ask for price

Ppp1r15a ORF Vector (Rat) (pORF)

ORF073908 1.0 ug DNA
EUR 607.2

PPP1R15A ORF Vector (Human) (pORF)

ORF008118 1.0 ug DNA
EUR 114

Ppp1r15a ORF Vector (Mouse) (pORF)

ORF054630 1.0 ug DNA
EUR 607.2

PPP1R15A ELISA Kit (Rat) (OKCD00864)

OKCD00864 96 Wells
EUR 1075.2
Description: Description of target: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3)."_x005F_x005F_x000D_Su Z.-Z., Emdad L., Sarkar D., Randolph A., Valerie K., Yacoub A., Dent P., Fisher P.B._x005F_x005F_x000D_Oncogene 24:2247-2255(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTANT PEG-3. ;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.118 ng/mL

Ppp1r15a (GFP-tagged) - Mouse protein phosphatase 1 regulatory (inhibitor) subunit 15A (Ppp1r15a), (10ug)

MG227514 10 µg Ask for price

Human PPP1R15A knockout cell line

ABC-KH12002 1 vial Ask for price
Description: Human PPP1R15A knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human PPP1R15A knockdown cell line

ABC-KD12002 1 vial Ask for price
Description: Human PPP1R15A knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human PPP1R15A Protein Lysate 20ug

IHUPPP1R15APLLY20UG each
EUR 213
Description: Human PPP1R15A Protein Lysate 20ug

PPP1R15A ELISA Kit (Mouse) (OKCD00311)

OKCD00311 96 Wells
EUR 1028.4
Description: Description of target: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication.5 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha."_x005F_x005F_x000D_Novoa I., Zeng H., Harding H.P., Ron D._x005F_x005F_x000D_J. Cell Biol. 153:1011-1022(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH PP1, MUTAGENESIS OF VAL-549.Ref.8"Stress-induced gene expression requires programmed recovery from translational repression."_x005F_x005F_x000D_Novoa I., Zhang Y., Zeng H., Jungreis R., Harding H.P., Ron D._x005F_x005F_x000D_EMBO J. 22:1180-1187(2003) [PubMed] [Europe PMC] [Abstract]Cited for: INDUCTION, FUNCTION.Ref.9"The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice."_x005F_x005F_x000D_Kojima E., Takeuchi A., Haneda M., Yagi A., Hasegawa T., Yamaki K., Takeda K., Akira S., Shimokata K., Isobe K._x005F_x005F_x000D_FASEB J. 17:1573-1575(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.Ref.10"Gadd34 requirement for normal hemoglobin synthesis."_x005F_x005F_x000D_Patterson A.D., Hollander M.C., Miller G.F., Fornace A.J. Jr._x005F_x005F_x000D_Mol. Cell. Biol. 26:1644-1653(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, DISRUPTION PHENOTYPE.Ref.11"Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway."_x005F_x005F_x000D_Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H._x005F_x005F_x000D_J. Virol. 81:11106-11115(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.057 ng/mL

PPP1R15A (Myc-DDK-tagged)-Human protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A)

RC200581 10 µg Ask for price

Ppp1r15a (Myc-DDK-tagged) - Mouse protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a)

MR227514 10 µg Ask for price

Ppp1r15a (untagged ORF) - Rat protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), (10 ug)

RN214180 10 µg Ask for price

OCOA11190-20UG - PPP1R15A Protein Lysate

OCOA11190-20UG 20ug
EUR 169

PPP1R15A Over-expression Lysate Product

GWB-3925D5 0.1 mg Ask for price

Goat Polyclonal Antibody against PPP1R15A

TA302708 100 µg Ask for price

h PPP1R15A inducible lentiviral particles

LVP854 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made over-expression lentivirus for expressing human target: h PPP1R15A (protein phosphatase 1, regulatory subunit 15A), [alternative names: GADD34]. The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_014330.3 . It also contains a RFP-Blasticidin dual selection marker.

OKCD00864-96W - PPP1R15A ELISA Kit (Rat)

OKCD00864-96W 96Wells
EUR 725

OPCA03491-20UG - PPP1R15A Recombinant Protein

OPCA03491-20UG 20ug
EUR 379

OPCD00533-10UG - PPP1R15A Recombinant Protein

OPCD00533-10UG 10ug
EUR 109

OPCD00533-50UG - PPP1R15A Recombinant Protein

OPCD00533-50UG 50ug
EUR 269

OPCD00534-10UG - PPP1R15A Recombinant Protein

OPCD00534-10UG 10ug
EUR 109

OPCD00534-50UG - PPP1R15A Recombinant Protein

OPCD00534-50UG 50ug
EUR 269

OPCA03491-100UG - PPP1R15A Recombinant Protein

OPCA03491-100UG 100ug
EUR 555

OPCA03491-500UG - PPP1R15A Recombinant Protein

OPCA03491-500UG 500ug
EUR 1534

OPCD00533-200UG - PPP1R15A Recombinant Protein

OPCD00533-200UG 200ug
EUR 529

OPCD00534-200UG - PPP1R15A Recombinant Protein

OPCD00534-200UG 200ug
EUR 529

Ppp1r15a (Myc-DDK-tagged ORF) - Rat protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), (10 ug)

RR214180 10 µg Ask for price

OKCD00311-96W - PPP1R15A ELISA Kit (Mouse)

OKCD00311-96W 96Wells
EUR 700

Ppp1r15a sgRNA CRISPR Lentivector set (Rat)

K6981701 3 x 1.0 ug
EUR 406.8

PPP1R15A 3'UTR GFP Stable Cell Line

TU068671 1.0 ml
EUR 1672.8

Ppp1r15a 3'UTR GFP Stable Cell Line

TU266657 1.0 ml Ask for price

Ppp1r15a 3'UTR GFP Stable Cell Line

TU166813 1.0 ml Ask for price

PPP1R15A sgRNA CRISPR Lentivector set (Human)

K1706801 3 x 1.0 ug
EUR 406.8

Ppp1r15a sgRNA CRISPR Lentivector set (Mouse)

K3806501 3 x 1.0 ug
EUR 406.8

Anti-GADD34/PPP1R15A Antibody Picoband™

A02394-2 10ug
EUR 154
Description: Western blot, 0.25-0.5 μg/ml, Human, Rat;_x000D_Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Human

Anti-GADD34/PPP1R15A Antibody Picoband™

A02394-3 10ug
EUR 154
Description: Western blot, 0.25-0.5 μg/ml, Human

Anti-GADD34/Ppp1r15a Antibody Picoband™

A02394-4 10ug
EUR 154
Description: Western blot, 0.25-0.5 μg/ml, Mouse;_x000D_Flow Cytometry, 1-3 μg/1x106 cells, Mouse;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Mouse

Lenti ORF clone of Ppp1r15a (mGFP-tagged) - Mouse protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a)

MR227514L4 10 µg Ask for price

PPP1R15A Protein Vector (Rat) (pPM-C-HA)

PV295632 500 ng
EUR 723.6

PPP1R15A Protein Vector (Rat) (pPB-C-His)

PV295630 500 ng
EUR 723.6

PPP1R15A Protein Vector (Rat) (pPB-N-His)

PV295631 500 ng
EUR 723.6

PPP1R15A Protein Vector (Rat) (pPM-C-His)

PV295633 500 ng
EUR 723.6

Lenti ORF clone of Ppp1r15a (Myc-DDK-tagged) - Mouse protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a)

MR227514L3 10 µg Ask for price

PPP1R15A Protein Vector (Human) (pPM-C-HA)

PV032471 500 ng
EUR 394.8

PPP1R15A Protein Vector (Mouse) (pPM-C-HA)

PV218520 500 ng
EUR 723.6

PPP1R15A Protein Vector (Human) (pPB-C-His)

PV032469 500 ng
EUR 394.8

PPP1R15A Protein Vector (Human) (pPB-N-His)

PV032470 500 ng
EUR 394.8

PPP1R15A Protein Vector (Human) (pPM-C-His)

PV032472 500 ng
EUR 394.8

PPP1R15A Protein Vector (Mouse) (pPB-C-His)

PV218518 500 ng
EUR 723.6

PPP1R15A Protein Vector (Mouse) (pPB-N-His)

PV218519 500 ng
EUR 723.6

PPP1R15A Protein Vector (Mouse) (pPM-C-His)

PV218521 500 ng
EUR 723.6

Ppp1r15a 3'UTR Luciferase Stable Cell Line

TU116813 1.0 ml Ask for price

PPP1R15A 3'UTR Luciferase Stable Cell Line

TU018671 1.0 ml
EUR 1672.8

Ppp1r15a 3'UTR Luciferase Stable Cell Line

TU216657 1.0 ml Ask for price

GADD34 (PPP1R15A) goat polyclonal antibody, Purified

SP1389P 100 µg Ask for price

Lenti ORF particles, PPP1R15A (mGFP-tagged) - Human protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A), 200ul, >10^7 TU/mL

RC200581L2V 200 µl Ask for price

Lenti ORF particles, PPP1R15A (mGFP-tagged) - Human protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A), 200ul, >10^7 TU/mL

RC200581L4V 200 µl Ask for price

Lenti ORF particles, Ppp1r15a (GFP-tagged) - Mouse protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), 200ul, >10^7 TU/mL

MR227514L4V 200 µl Ask for price

Ppp1r15a sgRNA CRISPR Lentivector (Rat) (Target 1)

K6981702 1.0 ug DNA
EUR 184.8

Ppp1r15a sgRNA CRISPR Lentivector (Rat) (Target 2)

K6981703 1.0 ug DNA
EUR 184.8

Ppp1r15a sgRNA CRISPR Lentivector (Rat) (Target 3)

K6981704 1.0 ug DNA
EUR 184.8

PPP1R15A sgRNA CRISPR Lentivector (Human) (Target 1)

K1706802 1.0 ug DNA
EUR 184.8

PPP1R15A sgRNA CRISPR Lentivector (Human) (Target 2)

K1706803 1.0 ug DNA
EUR 184.8

PPP1R15A sgRNA CRISPR Lentivector (Human) (Target 3)

K1706804 1.0 ug DNA
EUR 184.8

Ppp1r15a sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3806502 1.0 ug DNA
EUR 184.8

Ppp1r15a sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3806503 1.0 ug DNA
EUR 184.8

Ppp1r15a sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3806504 1.0 ug DNA
EUR 184.8

Lenti ORF clone of Ppp1r15a (mGFP-tagged ORF) - Rat protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), (10 ug)

RR214180L4 10 µg Ask for price

ARP63717_P050-25UL - PPP1R15A Antibody - N-terminal region

ARP63717_P050-25UL 25ul
EUR 99

Lenti ORF particles, PPP1R15A (Myc-DDK tagged) - Human protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A), 200ul, >10^7 TU/mL

RC200581L1V 200 µl Ask for price

Lenti ORF particles, PPP1R15A (Myc-DDK tagged) - Human protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A), 200ul, >10^7 TU/mL

RC200581L3V 200 µl Ask for price

Lenti ORF particles, Ppp1r15a (GFP-tagged ORF) - Rat protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), 200ul, >10^7 TU/mL

RR214180L4V 200 µl Ask for price

Lenti ORF particles, Ppp1r15a (Myc-DDK-tagged) - Mouse protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), 200ul, >10^7 TU/mL

MR227514L3V 200 µl Ask for price

AAP63717-100UG - PPP1R15A Peptide - N-terminal region

AAP63717-100UG 100ug
EUR 99

Lenti ORF clone of Ppp1r15a (Myc-DDK-tagged ORF) - Rat protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), (10 ug)

RR214180L3 10 µg Ask for price

Lenti ORF particles, Ppp1r15a (Myc-DDK-tagged ORF) - Rat protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a), 200ul, >10^7 TU/mL

RR214180L3V 200 µl Ask for price

ARP63717_P050 - PPP1R15A antibody - N-terminal region (ARP63717_P050)

ARP63717_P050 100ul
EUR 389

PPP1R15A Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV654781 1.0 ug DNA
EUR 818.4

PPP1R15A Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV654785 1.0 ug DNA
EUR 818.4

PPP1R15A Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV654786 1.0 ug DNA
EUR 818.4

Human Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

1-CSB-YP018528HU
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  • 1MG
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Description: Recombinant Human Protein phosphatase 1 regulatory subunit 15A(PPP1R15A),partial expressed in Yeast

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

20-abx325005
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  • 100 ug
  • 50 ug

Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) Antibody

abx412519-01mg 0.1 mg
EUR 961.2

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx430859-200ul 200 ul
EUR 460.8

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx036158-100ug 100 ug
EUR 469.2

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

20-abx131495
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

20-abx131496
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) Antibody

abx233293-100ug 100 ug
EUR 610.8

Protein Phosphatase 1, Regulatory Subunit 15A (Ppp1r15a) Antibody

20-abx114830
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  • 150 ul
  • 50 ul

Protein Phosphatase 1, Regulatory Subunit 15A (Ppp1r15a) Antibody

abx114830-100l 100 µl
EUR 612.5

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx131495-100g 100 µg
EUR 812.5

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx131495-20g 20 µg
EUR 362.5

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx131495-5g 5 µg
EUR 287.5

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx131496-100g 100 µg
EUR 775

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx131496-20g 20 µg
EUR 350

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx131496-5g 5 µg
EUR 275

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx036158-100g 100 µg
EUR 337.5

Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) Antibody

abx240211-100l 100 µl Ask for price

Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) Antibody

abx240211-50l 50 µl
EUR 350

Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A) Antibody

abx233293-100g 100 µg
EUR 350

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx325005-100g 100 µg
EUR 250

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx325005-50g 50 µg
EUR 187.5

Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) Antibody

abx430859-200l 200 µl
EUR 387.5

Ppp1r15a (Rat) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR513890 2 nmol Ask for price

Recombinant Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A)

RPU50570-100ug 100ug
EUR 419.1

Recombinant Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A)

RPU50570-1mg 1mg
EUR 1856.4

Recombinant Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A)

RPU50570-50ug 50ug
EUR 336.6

Recombinant Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A)

RPU50571-100ug 100ug
EUR 419.1

Recombinant Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A)

RPU50571-1mg 1mg
EUR 1856.4

In addition, Ppme1 promoter active in muscle cells, while mutation of conserved E-box element prevents full induction Ppme1 reporter gene, suggesting that Ppme1 is transcriptionally regulated by myogenic regulatory factors. Interestingly, immunofluorescence analysis showed that Ppme1 localized to both the cytoplasm and nucleus, whereas cell fractionation showed that Ppme1 only found in the cytoplasm. Functional studies revealed that the inhibition of muscle cell differentiation Ppme1 use AMZ30 ABL127 or attenuates.

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